Sodium Nitrite → HCID 53902840, compound

HRID 2051817Notes

Reaction equation

HRID 2051817 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH2:19][CH:20]([CH3:22])[CH3:21])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:23]([O-])=[O:24].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:23]=[O:24])[C:5]([N:7]([CH2:19][CH:20]([CH3:22])[CH3:21])[CH:8]1[O:16][C@H:15]([CH2:17][OH:18])[C@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 54093436HCID 54093436, compound

Product 1

HCID 53902840HCID 53902840, compoundYield 26.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

7.0 g of 1-(2-chloroethyl)-3-isobutyl-3-D-galactopyranosylurea are dissolved in 15 ml of formic acid, and 5.0 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is further stirred at the same temperature for one hour. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 2.0 g of 1-(2-chloroethyl)-1-nitroso-3-isobutyl-3-D-galactopyranosylurea are thereby obtained as a pale yellow powder.

Workup

  1. stirringThe mixture is further stirred at the same temperature for one hour
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-f9cbb1cc7abb4802aa0b1cf4140c2b42
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

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