Sodium Nitrite → HCID 13092731, compound

HRID 2051831Notes

Reaction equation

HRID 2051831 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH3:17])[CH:8]1[O:14][C@H:13]([CH2:15][OH:16])[C@@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:18]([O-])=[O:19].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:18]=[O:19])[C:5]([N:7]([CH3:17])[CH:8]1[O:14][C@H:13]([CH2:15][OH:16])[C@@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 54050138HCID 54050138, compound

Product 1

HCID 13092731HCID 13092731, compoundYield 63.2%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

2 g of 1-(2-chloroethyl)-3-methyl-3-D-ribofuranosylurea are dissolved in 10 ml of formic acid, and 1.1 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is further stirred at the same temperature for one hour. After the reaction, the mixture is treated in the same manner as described in Example 1-(2). 1.4 g of 1-(2-chloroethyl)-1-nitroso-3-methyl-3-D-ribofuranosylurea are thereby obtained as a yellow powder.

Workup

  1. stirringThe mixture is further stirred at the same temperature for one hour
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-1aefb5eaf95b43dea51b4316042d6a06
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

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