Sodium Carbonate → HCID 13092731, compound

Participants

Reaction Steps

2.7 g of 1-(2-chloroethyl)-3-methyl-3-D-ribofuranosylurea are dissolved in a mixture of 80 ml of tetrahydrofuran and 80 ml of methylene chloride, and 15 g of sodium carbonate anhydrate are added thereto. 5 g of nitrogen tetroxide gas are introduced into the mixture for 10 minutes under ice-cooling. The mixture is treated in the same manner as described in Example 2. 2.1 g of 1-(2-chloroethyl)-1-nitroso-3-methyl-3-ribofuranosylurea are thereby obtained as a yellow powder.

Provenance & Evidence