Sodium Nitrite → HCID 13092733, compound

HRID 2051834Notes

Reaction equation

HRID 2051834 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH2:17][CH2:18][CH2:19][CH3:20])[CH:8]1[O:14][C@H:13]([CH2:15][OH:16])[C@@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:21]([O-])=[O:22].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:21]=[O:22])[C:5]([N:7]([CH2:17][CH2:18][CH2:19][CH3:20])[CH:8]1[O:14][C@H:13]([CH2:15][OH:16])[C@@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 53956630HCID 53956630, compound

Product 1

HCID 13092733HCID 13092733, compoundYield 41.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

3.1 g of 1-(2-chloroethyl)-3-n-butyl-3-D-ribofuranosylurea are dissolved in 10 ml of formic acid, and 1.5 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is further stirred at the same temperature for one hour. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 1.4 g of 1-(2-chloroethyl)-1-nitroso-3-n-butyl-3-D-ribofuranosylurea are thereby obtained as yellow caramel.

Workup

  1. stirringThe mixture is further stirred at the same temperature for one hour
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-2c0b8c1fc40144ddbe41bdebe17a01b9
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

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