Sodium Nitrite → HCID 54068341, compound

HRID 2051839Notes

Reaction equation

HRID 2051839 reaction equation
[Cl:1][CH2:2][CH2:3][NH:4][C:5]([N:7]([CH2:17][CH2:18][CH3:19])[CH:8]1[O:16][CH2:15][C@@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6].[N:20]([O-])=[O:21].[Na+]>C(O)=O>[Cl:1][CH2:2][CH2:3][N:4]([N:20]=[O:21])[C:5]([N:7]([CH2:17][CH2:18][CH3:19])[CH:8]1[O:16][CH2:15][C@@H:13]([OH:14])[C@H:11]([OH:12])[C@H:9]1[OH:10])=[O:6]

Participants

4

Reactant 2

HCID 23668193Sodium NitriteHCID 54455417HCID 54455417, compound

Product 1

HCID 54068341HCID 54068341, compoundYield 37.5%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

9.0 g of 1-(2-chloroethyl)-3-n-propyl-3-D-xylopyranosylurea are dissolved in 25 ml of formic acid, and 6.0 g of sodium nitrite are added gradually thereto at 0° to 5° C. for one hour under stirring. The mixture is stirred at the same temperature for 30 minutes. After the reaction, the mixture is treated in the same manner as described in Example 5-(2). 3.7 g of 1-(2-chloroethyl)-1-nitroso-3-n-propyl-3-D-xylopyranosylurea are thereby obtained as pale yellow caramel.

Workup

  1. stirringThe mixture is stirred at the same temperature for 30 minutes
  2. customAfter the reaction
  3. additionthe mixture is treated in the same manner

Sources & evidence

ORD record
ord-fdcd8058e42844cfb85374b9d11482fc
Source dataset
uspto-grants-1980_01
Patent number
US04182757

Reaction notes

Loading…