Sodium Carbonate → HCID 13092741, compound

Participants

Reaction Steps

3.0 g of 1-(2-chloroethyl)-3-n-propyl-3-L-arabinopyranosylurea are dissolved in a mixture of 80 ml of tetrahydrofuran and 80 ml of methylene chloride, and 15 g of sodium carbonate are added thereto. 5 g of nitrogen tetroxide gas are introduced into the mixture for 10 minutes under ice-cooling. The mixture is treated in the same manner as described in Example 2. 2.5 g of 1-(2-chloroethyl)-1-nitroso-3-n-propyl-3-L-arabinopyranosylurea are thereby obtained as yellow caramel.

Provenance & Evidence