HCID 20378115, compound → HCID 20378104, compound

Participants

Reaction Steps

0.9 g of 1-(2-chloroethyl)-3-methyl-3-(2-hydroxyethyl)urea is dissolved in 10 ml of acetic acid, and 0.9 g of sodium nitrite is added thereto under stirring. The mixture is stirred at room temperature for one hour. Then, 0.5 g of sodium nitrite is again added to the mixture, and said mixture is further stirred at the same temperature for 4 hours. After the reaction, the mixture is freeze-dried, and the residue obtained is purified by silica gel chromatography (Solvent: chloroform-methanol=10:1). 0.7 g of 1-(2-chloroethyl)-1-nitroso-3-methyl-3-(2-hydroxyethyl)urea is thereby obtained as a pale yellow oil.

Provenance & Evidence