Hydrochloric Acid → HCID 20378109, compound

Participants

Reaction Steps

2.1 g of 1-(2-chloroethyl)-3-methyl-3-(2,3-dihydroxy-n-propyl)urea are dissolved in 10 ml of acetic acid, and 1.4 g of sodium nitrite are added thereto under stirring. The mixture is stirred at room temperature for 2 hours. Then, 2 ml of concentrated hydrochloric acid and one g of sodium nitrite are added to the mixture, and said mixture is further stirred at the same temperature for 2 hours. After the reaction, the mixture is treated in the same manner as described in Example 60-(2) (Solvent used for chromatography: chloroform-ethyl acetate-methanol(3:1:1)). 1.5 g of 1-(2-chloroethyl)-1-nitroso-3-methyl-3-(2,3-dihydroxy-n-propyl)urea are thereby obtained as a pale yellow oil.

Provenance & Evidence