Sodium Hydroxide → HCID 12901229, compound

HRID 2051882Notes

Reaction equation

HRID 2051882 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]3[C:16]=2[NH:15][C:14](=[O:17])[CH2:13]3)=[O:7])=[CH:4][CH:3]=1.[OH-:20].[Na+]>O>[NH2:15][C:16]1[C:8]([C:6](=[O:7])[C:5]2[CH:18]=[CH:19][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:9][CH:10]=[CH:11][C:12]=1[CH2:13][C:14]([OH:20])=[O:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12901224HCID 12901224, compound

Product 1

HCID 12901229HCID 12901229, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.5 g. (0.006 mole) of 7-(4-fluorobenzoyl) indolin-2-one in 50 ml. of 3 N sodium hydroxide was refluxed under nitrogen for 45 min. The solution was cooled, diluted with an equal volume of water, filtered, and the filtrate was extracted two times with 50 ml. of ether. The aqueous basic solution was treated dropwise with glacial acetic acid until a heavy yellow precipitate formed. The precipitate was filtered off, washed thoroughly with water and air-dried. The yield was 1.1 g. (68%); m.p. 136°-137° C.

Workup

  1. additionA mixture of 1.5 g
  2. temperatureThe solution was cooled
  3. filtrationfiltered
  4. extractionthe filtrate was extracted two times with 50 ml
  5. additionThe aqueous basic solution was treated dropwise with glacial acetic acid until a heavy yellow precipitate
  6. customformed
  7. filtrationThe precipitate was filtered off
  8. washwashed thoroughly with water
  9. customair-dried

Sources & evidence

ORD record
ord-74cc7a58287a4d6f9a4946528038e75e
Source dataset
uspto-grants-1980_01
Patent number
US04182774

Reaction notes

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