Amfenac → Magnesium;bis(2-(2-amino-3-benzoylphenyl)acetate);trihydrate

HRID 2051884Notes

Reaction equation

HRID 2051884 reaction equation
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([OH:19])=[O:18].[Cl-].[Mg+2:21].[Cl-]>>[OH2:15].[OH2:15].[OH2:15].[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([O-:19])=[O:18].[Mg+2:21].[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 2136AmfenacHCID 5360315Magnesium Chloride

Product 1

HCID 12901240Magnesium;bis(2-(2-amino-3-benzoylphenyl)acetate);trihydrate

Procedure

An aqueous solution of 6.36 g. (0.02 mole) of 2-amino-3-benzoylphenylacetic acid was treated with an aqueous solution of magnesium chloride (0.01 mole). A precipitate formed immediately. After 15 min. of stirring, the bright yellow precipitate was filtered and dried. The yield was 4.06 g. and the salt melted over the broad range of 150°-190° C.

Workup

  1. customA precipitate formed immediately
  2. filtrationthe bright yellow precipitate was filtered
  3. customdried
  4. custommelted over the broad range of 150°-190° C.

Sources & evidence

ORD record
ord-9ec3e82109f4416a9a5e2bd2d7bca2b9
Source dataset
uspto-grants-1980_01
Patent number
US04182774

Reaction notes

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