Benzocaine → HCID 23468284, compound

Participants

Reaction Steps

A solution of 10.0 g of 6-(2-naphthyloxy)-1-hexanol O-methanesulfonate and 9.7 g of ethyl 4-aminobenzoate in 50 ml of hexamethylphosphoramide is heated at 110° C. for 16 hours. The solution is cooled, diluted with water, filtered and the solid washed with ethanol and water to give 7.7 g of product. Recrystallization from ethanol and once from acetone-hexane gives crystals, mp 109°-110° C.

Provenance & Evidence