Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | Benzene, (2-bromoethoxy)- | HCID 68526 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 20378381 | HCID 20378381 | — |
Reaction Steps
A mixture of 33 g of ethyl p-aminobenzoate, 80 ml of hexamethylphosphoramide and 20.1 g of β-bromophenetole is heated at 110° C. for 20 hours. The mixture is cooled, diluted with 25 ml of water, chilled, filtered and the solid washed with ethanol and with water to give crystals, mp 126°-129° C. Recrystallization from ethanol gives pale yellow crystals, mp 129°-131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04182776 |
|---|
| Source dataset | uspto-grants-1980_01 |
|---|
| ORD ID | ord-7ac1ae2d14734c9f8dfc8d5f3e7ea411 |
|---|
| Source note | uspto-grants-1980_01 |
|---|
