Water → HCID 20378383, compound

Participants

Reaction Steps

A solution of 5.5 g of 4-(3-phenoxypropylamino)benzoic acid, 4.80 g of 25% aqueous sodium hydroxide, and 12.6 g of 3-iodo-1,2-propanediol in 50 ml of hexamethylphosphoramide is stirred for 24 hours at ambient temperature, diluted with 100 ml of ether and stirred for 5 days at ambient temperature. The mixture is treated with water and extracted with ether. The dried extracts are evaporated to yield 2,3-dihydroxypropyl 4-(3-phenoxypropylamino)benzoate as a white solid.

Provenance & Evidence