3-Chloro-1,2-propanediol → HCID 20378383, compound

Participants

Reaction Steps

A solution of 5.5 g. of 4-(3-phenoxypropylamino)benzoic acid in 50 ml. of hexamethylphosphoramide is treated with 4.80 g. of 25% aqueous sodium hydroxide followed by 11.0 g. of 3-chloro-1,2-propanediol and then is heated at 140° C. for 6 hours. The mixture is diluted with water and ether and filtered to yield a white solid. Recrystallization from acetonitrile affords pure 2,3-dihydroxypropyl 4-(3-phenoxypropylamino)benzoate as a white crystalline solid.

Provenance & Evidence