Chloroform → 2-(4-Fluorophenoxy)ethanol

Participants

Reaction Steps

To 200 ml of 1 M diborane in tetrahydrofuran was added dropwise 17.0 L g of 4-fluorophenoxyacetic acid in 100 ml of tetrahydrofuran at 5°-10° C. The reaction was stirred at room temperature overnight and poured into a mixture of 100 ml of ice and 750 ml of chloroform. The water phase was extracted twice more with 250 ml each of chloroform and the combined organic phase dried. This solution was concentrated to a light yellow oil. This material was placed on the Kugelrohr (vacuum distillation) giving 14.8 g on distillation.

Provenance & Evidence