Acetic Anhydride → HCID 20378264, compound

HRID 2051954Notes

Reaction equation

HRID 2051954 reaction equation
[C:1]1([C:7]2[N:8]=[C:9]([S:18][C:19]([F:24])([F:23])[CH:20]([F:22])[F:21])[NH:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:25](OC(=O)C)(=[O:27])[CH3:26]>>[C:25]([N:10]1[C:11]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]=[C:9]1[S:18][C:19]([F:23])([F:24])[CH:20]([F:22])[F:21])(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 135080754,5-Diphenyl-2-(1,1,2,2-tetrafluoroethylthio)imidazole

Product 1

HCID 20378264HCID 20378264, compound

Procedure

A mixture of 1.8 g (0.005 mole) of 4,5-diphenyl-2-(1,1,2,2-tetrafluoroethylthio)imidazole and 25 ml acetic anhydride was heated at reflux seven hours, then cooled and stirred at room temperature for four days. Most of the acetic anhydride and acetic acid were removed at reduced pressure (~0.5 mm). The white solid residue was chromatographed on silica gel, eluting with toluene, to give 0.8 g of white product, mp 143°-4° (from hexane).

Workup

  1. temperaturewas heated
  2. temperatureat reflux seven hours
  3. temperaturecooled
  4. customMost of the acetic anhydride and acetic acid were removed at reduced pressure (~0.5 mm)
  5. customThe white solid residue was chromatographed on silica gel
  6. washeluting with toluene

Sources & evidence

ORD record
ord-cb313f7d67234d589c7d63a458f7321b
Source dataset
uspto-grants-1980_01
Patent number
US04182769

Reaction notes

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