HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formic Acid → Fosmidomycin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Magnesium Hydroxide | HCID 73981 | — |
| Reactant | 3-(Hydroxyamino)propylphosphonic acid | HCID 342170 | — |
| Solvent | Water | HCID 962 | — |
| Product | Fosmidomycin | HCID 572 | 65.8% |
Reaction Steps
An oily 3-(N-formyl-N-hydroxyamino)propylphosphonic acid (12.05 g.), which was prepared by the reaction of 3-(N-hydroxyamino)propylphosphonic acid (15.5 g.), acetic anhydride (12.3 g.) and formic acid (9.8 ml.) conducted in substantially the same manner as that of Example (31), was dissolved in water (80 ml.) and treated with magnesium hydroxide (5.83 g.) for 15 minutes under ice-cooling with stirring.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04182758 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-62e0531f603544e8818ebff1f23c9af7 |
| Source note | uspto-grants-1980_01 |