Sodium Hydroxide → HCID 20378451, compound

Participants

Reaction Steps

19.1 g of N,N'-diacetyl-1,4-diamino-2-(p-dimethylaminophenyl)-3-phenyl-butane in 80 ml of 15% strength aqueous sodium hydroxide solution are heated to 200° C. in an autoclave for 16 hours. The reaction solution is then concentrated in a rotary evaporator and extracted with chloroform. After removing the chloroform in vacuo, 8.5 g of crystalline crude amine are obtained and this is recrystallised from 35 ml of isopropanol. Yield: 3.8 g of product having a melting point of 145°-146° C. A further 2.0 g of product having a melting point of 145°-146° C. are obtained by concentrating.

Provenance & Evidence