HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2052022Generated: October 31, 2026
Acetic Anhydride → 2,3-Dichloro-4-(2-phenylacryloyl)anisole
https://huagongshe.com/reaction/2052022
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2,3-Dichloro-4-phenylacetylanisole | HCID 11130195 | — |
| Solvent | N,N,N',N'-Tetramethylmethanediamine | HCID 5829 | — |
| Product | 2,3-Dichloro-4-(2-phenylacryloyl)anisole | HCID 10924810 | — |
Reaction Steps
Acetic anhydride (100 ml.) is added dropwise to a suspension of 2,3-dichloro-4-phenylacetylanisole (29.5 g., 0.01 mole) in bis(dimethylamino)methane (100 ml.) under nitrogen with cooling to maintain the reaction mixture temperature below 60° C. The reaction mixture is stirred at 25° C. for 2 hours, and poured into ice water (1500 ml.) to precipitate 7.4 g. of 2,3-dichloro-4-(2-phenylacryloyl)anisole which melts at 87°-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04182764 |
|---|
| Source dataset | uspto-grants-1980_01 |
|---|
| ORD ID | ord-f746fb51c32a4f03b49bdbbd403432b3 |
|---|
| Source note | uspto-grants-1980_01 |
|---|
