反应详情

温度

0 °C

(1-Oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxy)acetic acid (0.50 g., 0.0014 mole) is added portionwise with stirring to chlorosulfonic acid (5 ml.) in an ice-water bath. The reaction mixture is stirred at 0° C. for 2 hours, left to come to ambient temperature for 2 hours, then slowly added to crushed ice to precipitate 0.51 g. of [1-oxo-2-(4-chlorosulfonylphenyl)-2-methyl-6,7-dichloro-5-indanyloxy]acetic acid which melts at 209°-210° C. after crystallization from acetic acid:water, 3:2.

1. waitleft
2. waitto come to ambient temperature for 2 hours
3. additionslowly added
4. customto crushed ice
5. customto precipitate 0.51 g
6. customof [1-oxo-2-(4-chlorosulfonylphenyl)-2-methyl-6,7-dichloro-5-indanyloxy]acetic acid which melts at 209°-210° C. after crystallization from acetic acid