Methyl iodide → HCID 178503858, compound

HRID 2052065Notes

Reaction equation

HRID 2052065 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[N:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[S:9].[CH3:17][I:18]>CC(C)=O>[IH:18].[CH3:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[N:7][C:8]([S:9][CH3:17])=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178480600HCID 178480600, compound

Product 1

HCID 178503858HCID 178503858, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 22.0 g (0.094 mole) of N-(1-methyl-2-imidazolidinylidene)-N'-phenylthiourea and 14.9 g (0.105 mole) of methyliodide in 500 ml of acetone is refluxed for 2.5 hours. The reaction mixture is evaporated in vacuo and the oil obtained is crystallized from acetone-ether (1:1) to give 30 g (85%) of methyl N-(1-methyl-2-imidazolidinylidene)-N'-phenylcarbamimidothioate hydroiodide; m.p. 122°-126° C.

Workup

  1. temperatureis refluxed for 2.5 hours
  2. customThe reaction mixture is evaporated in vacuo
  3. customthe oil obtained
  4. customis crystallized from acetone-ether (1:1)

Sources & evidence

ORD record
ord-db285d20457145e0a1d5d20d19f833cd
Source dataset
uspto-grants-1980_01
Patent number
US04182865

Reaction notes

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