Sodium Hydroxide → HCID 20378662, compound

HRID 2052118Notes

Reaction equation

HRID 2052118 reaction equation
[C:1]([N:11]1[CH2:32][CH2:31][N:14]2[C:15]3[C:20]([NH:21][C:22](=[O:23])[CH:13]2[CH2:12]1)=[CH:19][C:18]([NH:24]C(=O)C(F)(F)F)=[CH:17][CH:16]=3)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[OH-].[Na+]>O>[NH2:24][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[N:14]1[CH2:31][CH2:32][N:11]([C:1]([O:3][CH2:4][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=3)=[O:2])[CH2:12][CH:13]1[C:22](=[O:23])[NH:21]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20378647HCID 20378647, compound

Product 1

HCID 20378662HCID 20378662, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2.8 g. of 3-carbobenzoxy-2,3,4,4a-Tetrahydro-8-(2,2,2-trifluoroacetamido)-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one, 0.5 g. of sodium hydroxide and 200 ml. of water is boiled for 15 minutes, then cooled. The mixture is then extracted with methylene chloride. The organic portion is then extracted with dilute hydrochloric acid. The aqueous acid phase is then basified with dilute sodium hydroxide and extracted with methylene chloride. The organic phase is dried and concentrated to give 1.6 g. of pale yellow solid product, m.p. 130°-135°.

Workup

  1. additionA mixture of 2.8 g
  2. temperaturecooled
  3. extractionThe mixture is then extracted with methylene chloride
  4. extractionThe organic portion is then extracted with dilute hydrochloric acid
  5. extractionextracted with methylene chloride
  6. customThe organic phase is dried
  7. concentrationconcentrated
  8. customto give 1.6 g

Sources & evidence

ORD record
ord-c7d2c06e30244b209e73c413eb6643f4
Source dataset
uspto-grants-1980_01
Patent number
US04182872

Reaction notes

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