Sodium Dithionite → HCID 20378815, compound

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Reaction Steps

In 340 cc of a 1:1 (by volume) mixture of methanol-water containing 43 g of Na2S2O4 were suspended 34.4 millimols of 4-[(3,3-dichloropropenyl)-thio]-2-nitroaniline. The reduction of the nitro-group was achieved in very short times (10-15 min.) as was ascertained by thin-layer chromatography. After the reduction was completed, the methanol and part of the water were removed under vacuum thereby obtaining an oily suspension which was then extracted with chloroform. The organic extracts, after drying on anhydrous Na2SO4, and evaporation of the solvent under vacuum, yielded, with practically quantitative yields, the raw diamine (an intensely colored thick oil) which was directly used for the successive stage.

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