反应详情

A suspension of 24.9 gm (0.1 mol) of 2,6-dichloro-4-phenyl-3-cyano-pyridine in 400 ml of ethanol was slowly admixed with 17.4 gm (0.2 mol) of morpholine, and the resulting mixture was refluxed for about two hours. Even while refluxing, but primarily upon subsequent cooling (optionally on an ice water bath) of the reaction mixture, a colorless crystalline precipitate formed which was collected by suction filtration, very thoroughly washed with water and dried. 25.8 gm (86% of theory) of 2-chloro-6-morpholino-4-phenyl-3-cyanopyridine, m.p. 198°-200° C., were obtained.

1. temperaturethe resulting mixture was refluxed for about two hours
2. temperatureEven while refluxing
3. temperatureprimarily upon subsequent cooling (optionally on an ice water bath) of the reaction mixture
4. customa colorless crystalline precipitate formed which
5. filtrationwas collected by suction filtration
6. washvery thoroughly washed with water
7. customdried