反应详情

温度

170 °C

A mixture consisting of 3.0 gm (0.01 mol) of 2-chloro-6-morpholino-4-phenyl-3-cyano-pyridine, 1.4 gm (0.03 mol) of methyl-hydrazine and 4 ml of ethylene glycol was refluxed for 3 hours at 170° C. (bath temperature). The resulting solution was then taken up in 50 ml of water, whereupon the reaction product initially separated out as a pasty precipitate. The pasty product was collected and digested with water, and after it has solidified it was suction-filtered off, washed and dried, yielding 2.8 gm (91% of theory) of the compound of the formula ##STR7## After recrystallizing the product over from methanol it had a melting point of 149°-152° C.

1. custominitially separated out as a pasty precipitate
2. customThe pasty product was collected
3. filtrationwas suction-filtered off
4. washwashed
5. customdried
6. customyielding 2.8 gm (91% of theory) of the compound of the formula
7. custom##STR7## After recrystallizing the product over from methanol it