Cyanamide → HCID 178439143, compound

Participants

Reaction Steps

In 200 ml of ethanol were dissolved 24.3 g of the phenyl α-methyl-β-(m-aminophenyl)-propionate hydrochloride obtained and 4.2 g of cyanamide, and the solution was subjected to reaction at 70° C. for 5 hours. After the reaction, the solvent was removed by distillation under reduced pressure to obtain phenyl α-methyl-β-(m-guanidinophenyl)-propionate hydrochloride in the form of an oily matter. This was dissolved in 50 ml of ethanol and then added to saturated aqueous NaHCO3 solution, upon which colorless crystals precipitated. The crystals were collected by filtration and washed with water and acetone, to obtain phenyl α-methyl-β-(m-guanidinophenyl)-propionate carbonate. Yield: 22.6 g (75%); melting point: 97°-98° C.; IR (cm-1): 3500-2500, 1745, 1682, 1625; MS: M+= m/e 297 (M.W.-H2CO3).

Provenance & Evidence