Diethyl Ether → HCID 178469093, compound

Participants

Reaction Steps

In 200 ml of ethanol were dissolved 28.6 g of the p-ethoxycarbonylphenyl β-(p-aminophenyl)-propionate hydrochloride obtained and 4.2 g of cyanamide, and the solution was subjected to reaction at 70° C. for 5 hours. After the reaction, the solvent was removed by distillation under reduced pressure to obtain an oily product, to which a mixture consisting of ethanol and diethyl ether was added and the solution was cooled, upon which crystals precipitated. The crystals were collected by filtration and recrystallized from an ethanol-diethyl ether mixture to obtain p-ethoxycarbonylphenyl β-(p-guanidinophenyl)propionate hydrochloride in the form of colorless crystals. Yield: 25.1 g (78%); melting point: 125°-127° C.; IR (cm-1): 3500-2550, 1750, 1708, 1670, 1599; MS: M+= m/e 355 (M.W. - HCl).

Provenance & Evidence