Trifluoroacetic acid → HCID 131711675, compound

Participants

Reaction Steps

A mixture of 0.11 g of benzhydryl 7-(2-methoxyimino-2-phenylacetamido)-3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)-3-cephem-4-carboxylate (obtained in Example 48), 2 ml of anisole and 4 ml of trifluoroacetic acid is stirred for 30 minutes at room temperature. After removal of the solvent under reduced pressure, the residue is triturated with the addition of absolute ether. The precipitates are filtered, and washed with ether to give 0.058 g of 7-(2-methoxyimino-2-phenylacetamido)-3-(5-dimethylamino-1,3,4-thiadiazol-2-yl)-3-cephem-4-carboxylic acid.

Provenance & Evidence