2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → HCID 70581734, compound

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Reaction Steps

To a solution of 1 g of benzhydryl 7-thienylacetamido-3-thiobenzoylhydrazonomethyl-3-cephem-4-carboxylate in 10 ml of dioxane is added 0.28 g of DDQ, followed by stirring at room temperature for 30 minutes. The reaction mixture is filtered and the filtrate cake is washed with a small amount of dioxane. The combined filtrate is evaporated to dryness in vacuo and the residue recrystallized from ethyl acetate to give 0.6 g of benzhydryl 7-thienylacetamido-3-(5-phenyl-1,3,4-thiadiazol-2-yl)-3-cephem-4-carboxylate as pale yellow crystals.

Provenance & Evidence