反应详情

2-(4-Pyridyl)-s-triazolo[1,5-a]pyridine (4.0g) prepared as in Example I stage (a) was dissolved in methanol (20 ml), and dimethyl sulphate (1.30g) was added. The mixture was refluxed for 1 hour, and methanol (20 ml) was added. The mixture was then heated to give a solution, which was left to crystallise to yield 4.9g of 2-(1-methylpyridinium-4-yl)-s-triazolo[1,5-a] pyridine methyl sulphate, m.p. 276°-280° C. (decomp).

1. temperatureThe mixture was refluxed for 1 hour
2. temperatureThe mixture was then heated
3. customto give a solution, which
4. waitwas left
5. customto crystallise