Dimethyl Sulfate → HCID 86736774, compound

HRID 2052190Notes

Reaction equation

HRID 2052190 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:15]=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)=[CH:3][CH:2]=1.[S:16]([O:21]C)([O:19][CH3:20])(=[O:18])=[O:17]>CO>[CH3:20][O:19][S:16]([O-:21])(=[O:18])=[O:17].[CH3:20][N+:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:15]=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6497Dimethyl SulfateHCID 607310HCID 607310, compound

Product 1

HCID 86736774HCID 86736774, compoundYield 295%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2-(4-Pyridyl)-s-triazolo[1,5-a]pyridine (4.0g) prepared as in Example I stage (a) was dissolved in methanol (20 ml), and dimethyl sulphate (1.30g) was added. The mixture was refluxed for 1 hour, and methanol (20 ml) was added. The mixture was then heated to give a solution, which was left to crystallise to yield 4.9g of 2-(1-methylpyridinium-4-yl)-s-triazolo[1,5-a] pyridine methyl sulphate, m.p. 276°-280° C. (decomp).

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. temperatureThe mixture was then heated
  3. customto give a solution, which
  4. waitwas left
  5. customto crystallise

Sources & evidence

ORD record
ord-662770f5c6074789b1b7e8296e01d5e3
Source dataset
uspto-grants-1980_01
Patent number
US04183741

Reaction notes

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