Ethyl bromoacetate → HCID 86736775, compound

HRID 2052191Notes

Reaction equation

HRID 2052191 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:15]=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)=[CH:3][CH:2]=1.[Br:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19]>CCOCC>[Br-:16].[CH2:21]([O:20][C:18]([CH2:17][N+:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:15]=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)=[CH:3][CH:2]=1)=[O:19])[CH3:22]

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 607310HCID 607310, compound

Product 1

HCID 86736775HCID 86736775, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
100 °C

Procedure

2-(4-Pyridyl)-s-triazolo[1,5-a]pyridine (10.0g), prepared as in Example I stage (a) was added to ethyl bromoacetate (25 ml). The mixture was heated to 100° C. for 1 hour, cooled and diluted with ether (80 ml). The solid which formed was filtered off, washed with ether and dried. Recrystallisation from methanol yielded 13.9g of 2-(1-ethoxycarbonylmethylpyridinium-4-yl)-s-triazolo[1,5-a]pyridine bromide, m.p. 174°-176° C.

Workup

  1. temperaturecooled
  2. customThe solid which formed
  3. filtrationwas filtered off
  4. washwashed with ether
  5. customdried
  6. customRecrystallisation from methanol

Sources & evidence

ORD record
ord-6716c4eaad6542489b37c7314c0ab3d4
Source dataset
uspto-grants-1980_01
Patent number
US04183741

Reaction notes

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