Chloroacetone → HCID 20377085, compound

HRID 2052194Notes

Reaction equation

HRID 2052194 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:16]=[C:10]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][N:9]2[N:8]=1.[Cl:17][CH2:18][C:19](=[O:21])[CH3:20]>CCOCC>[Cl-:17].[CH2:18]([N+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:16]=[C:10]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][N:9]2[N:8]=1)[C:19]([CH3:20])=[O:21]

Participants

4

Reactant 2

HCID 6571ChloroacetoneHCID 20377090HCID 20377090, compound

Product 1

HCID 20377085HCID 20377085, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-(2-Pyridyl)-7-methyl-s-triazolo[1,5-a]pyridine (10 g) was added to chloroacetone (30 ml) and the mixture was refluxed for 2 hours. The mixture was cooled, and ether (100 ml) was added. The solid was filtered off, washed with ether, and dried in vacuo to give 1-acetonyl-2-(7-methyl-s-triazolo[1,5-a]pyridin-2-yl)pyridinium chloride. The product was then added to phosphorus trichloride (25 ml) and refluxed for 30 minutes, then cooled, and ether (100 ml) was added. The solid was filtered off, washed with ether, and dried in vacuo, to give 6.8 g of 7,10-dimethyl-pyrido[1,2-a]pyrido[1',2'-1,5]-s-triazolo[3,4-c]pyrazinedium dichloride, mp 186°-188° C.

Workup

  1. temperaturethe mixture was refluxed for 2 hours
  2. temperatureThe mixture was cooled
  3. filtrationThe solid was filtered off
  4. washwashed with ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-6bd017445ca04d7a8e5bf6ab42302c94
Source dataset
uspto-grants-1980_01
Patent number
US04183741

Reaction notes

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