HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylcarbamoyl Chloride → HCID 20377187, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | 2-Amino-4-methylthiazole | HCID 74143 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 20377187 | HCID 20377187 | 93.5% |
Reaction Steps
A mixture of 2-amino-4-methylthiazole (1.14 g), N,N-dimethylcarbamoyl chloride (1.29 g), aluminum chloride (1.60 g), and xylene (40 ml) is refluxed for 20 hours. The reaction mixture is worked up as in Example 1, whereby 1,1-dimethyl-3-(4-methyl-2-thiazolyl)urea (1.73 g) is obtained. Yield is 93.5%. Melting point is 97° to 98° C. (Pure product is recrystallized from ether/petroleum ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04183856 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-838390474dc449ff80517a25835347af |
| Source note | uspto-grants-1980_01 |