Sodium Hydroxide → HCID 20377507, compound

Participants

Reaction Steps

A mixture was prepared containing 55.5 grams (0.440 mole) of 4-hydroxybenzenethiol, 88.0 grams (0.440 mole) of 20% sodium hydroxide, and 160 ml of water. To this 72.0 grams of 4-(3-chloropropyl)morpholine was added. The reaction mixture was heated to reflux with stirring and immediately after cooled and diluted with water. The product separated out as an oil, but crystallized upon standing. Recrystallization from methylcyclohexane and ethanol gave white crystals of 4-(3-(4-hydroxyphenylthio)-propyl)morpholine having a melting point of 130.5°-131° C.

Provenance & Evidence