Sodium Hydroxide → HCID 178525258, compound

HRID 2052249Notes

Reaction equation

HRID 2052249 reaction equation
C(OC(CO[CH2:8][C:9]1[N:13](CC2C=CC(OC)=CC=2)[C:12]([SH:23])=[N:11][N:10]=1)=O)C.C([O:26][C:27](COCC(NN)=O)=[O:28])C.[OH-].[Na+]>>[C:27]([CH2:8][C:9]1[N:13]=[C:12]([SH:23])[NH:11][N:10]=1)([OH:28])=[O:26]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 20377449HCID 20377449, compoundHCID 178473061HCID 178473061, compound

Product 1

HCID 178525258HCID 178525258, compound

Procedure

By employing a procedure similar to that described in Example XVI, Part A, 3-(ethoxycarbonylmethoxymethyl)-4-(p-methoxybenzyl)-1,2,4-triazole-5-thiol was prepared from ethoxycarbonylmethoxyacetohydrazide. The ethoxycarbonyl group was then hydrolyzed to the free acid using aqueous 2 N sodium hydroxide, and the p-methoxybenzyl blocking group was thereafter removed by using trifluoroacetic acid in a manner similar to that earlier described in Example XVI, Part B to finally give pure 3-(carboxymethoxymethyl)-1,2,4-triazole-5-thiol, m.p. 180°-182° C.

Workup

  1. customthe p-methoxybenzyl blocking group was thereafter removed

Sources & evidence

ORD record
ord-6622df1690bd478baaed820284b872a8
Source dataset
uspto-grants-1980_01
Patent number
US04183925

Reaction notes

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