Benzyl mercaptan → HCID 56624110, compound

Participants

Reaction Steps

To 2.25 gm. of sodium metal dissolved in 185 ml. of ethanol is added 8.2 ml. of benzyl mercaptan followed by 3 gm. of 17β-methanesulfonyloxy-1,4-androstadiene-3-one. The reactants are heated to reflux for 48 hours. Pour the reaction mixture into 5% NaOH solution and extract with ethyl acetate. Wash the ethyl acetate extracts with water, dry over Na2SO4, and evaporate to a residue. The residue is purified on a 300 gm. silica gel column eluting with chloroform/ethyl acetate (2:1) to obtain the title compound.

Provenance & Evidence