HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 131711697, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl (S)-(2-((2,5-dioxo-1-pyrrolidinyl)oxy)-1-(1H-indol-3-ylmethyl)-2-oxoethyl)carbamate | HCID 98767 | — |
| Reactant | HCID 131711698 | HCID 131711698 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131711697 | HCID 131711697 | 97.5% |
Reaction Steps
1.57 g (3.78 mmoles of H-Nle-Asp-D-Phg-NH2.HCl are reacted with 1.52 g (3.78 mmoles) of BOC-Trp-OSu in 50 ml of DMF in the presence of 1.06 ml (7.6 mmoles) of triethylamine. Next day the reaction mixture is evaporated in vacuo, the residue is admixed with water, and the suspension is filtered. 2.45 g (97.5%) of BOC-Trp-Nle-Asp-D-Phg-NH2 are obtained; m.p.: 217° C. (decomposition), Rf5 :0.35, [α]D -32.7° (c: 1.0, in dimethyl formamide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04183909 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-ac74d92dc2fd4bc9bc97c3c08675c019 |
| Source note | uspto-grants-1980_01 |