HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 131711702, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl (S)-(2-((2,5-dioxo-1-pyrrolidinyl)oxy)-1-(1H-indol-3-ylmethyl)-2-oxoethyl)carbamate | HCID 98767 | — |
| Reactant | HCID 131711703 | HCID 131711703 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131711702 | HCID 131711702 | 66.2% |
Reaction Steps
1.50 g (3.74 mmoles) of H-Nva-Asp-D-Phg-NH2.HCl are reacted with 1.50 g (3.74 mmoles) of BOC-Trp-OSu in 30 ml of DMF in the presence of 1.05 ml (7.5 mmoles) of triethylamine. Next day the reaction mixture is evaporated in vacuo, the residue is admixed with water, and the mixture is filtered. The obtained crude product, weighing 2.36 g, is recrystallized from 300 ml of 80% ethanol. 1.54 g (66.2%) of BOC-Trp-Nva-Asp-D-Phg-NH2 are obtained; m.p.: 240° C. (decomposition), Rf5 :0.35, [α]D :-60.5° (c: 1.0, in dimethyl formamide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04183909 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-a158547135d84688860622d6ba4f49db |
| Source note | uspto-grants-1980_01 |