Water → HCID 135737545, compound

HRID 2052277Notes

Reaction equation

HRID 2052277 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[N:12]=[N:13][N:14]=[C:7]1[N:6]=[C:5]2[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[BH4-].[Na+].O>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[N:12]=[N:13][N:14]=[C:7]1[NH:6][CH:5]2[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 962WaterHCID 746189HCID 746189, compoundHCID 4311764Sodium borohydride

Product 1

HCID 135737545HCID 135737545, compoundYield 74.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 1.3 g of 7-chloro-5-phenyltetrazolo[1,5-a]quinazoline in 100 ml of ethanol was added 0.2 g of sodium borohydride. The mixture was stirred at room temperature for 1 hour and then poured into 200 ml of water. The resulting precipitate was collected by filtration, washed with water and recrystallized from methanol to give 0.98 g of 7-chloro-4,5-dihydro-5-phenyltetrazolo[1,5-a]quinazoline as colorless needles, m.p. 260°-261° C. (decomp.).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with water
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-0dc3b9f769454662867ba19b48e255dd
Source dataset
uspto-grants-1980_01
Patent number
US04183932

Reaction notes

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