Hydrochloric Acid → HCID 136005323, compound

Participants

Reaction Steps

To a suspension of 1.3 g of 7-chloro-1-methyl-5-phenyl-s-triazolo[4,3-a]quinazoline in 70 ml of dimethylformamide was added 0.5 g of sodium borohydride. The mixture was heated with stirring at 75°-80° C. for 2 hours and then poured into ice-water. The resulting mixture was neutralized with dilute hydrochloric acid, and the precipitate formed was collected by filtration and washed with water. The solid was then suspended in a mixture of 40 ml of methanol and 5 ml of concentrated hydrochloric acid, and the mixture was stirred at room temperature for 2 hours. After neutralization with ammonia water, the mixture was extracted with chloroform. The chloroform layer was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was recrystallized from dimethylformamideethanol to give 0.75 g of 7-chloro-4,5-dihydro-1-methyl-5-phenyl-s-triazolo[4,3-a]quinazoline as colorless needles, m.p. 262°-265° C.

Provenance & Evidence