Sodium borohydride → HCID 20377591, compound

Participants

Reaction Steps

To a suspension of 0.28 g of 7-chloro-5-phenylimidazo[1,2-a]quinazoline in 20 ml of ethanol was added 0.2 g of sodium borohydride, and the mixture was heated under reflux for 10 hours. After cooling, the mixture was poured into ice-water, and the resulting precipitate was collected by filtration, washed with water and dried. The product was dissolved in chloroform and absorbed on an activated alumina column. Elution with chloroform and recrystallization from ethanol gave 7-chloro-4,5-dihydro-5-phenylimidazo[1,2-a]quinazoline (m.p. 239°-241° C.) and 7-chloro-1,2,4,5-tetrahydro-5-phenylimidazo[1,2-a]quinazoline (m.p. 210°-213° C.).

Provenance & Evidence