Sodium Azide → HCID 20377607, compound

HRID 2052287Notes

Reaction equation

HRID 2052287 reaction equation
Cl[C:2]1[N:11]([CH3:12])[CH:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:19])[CH:8]=2)[N:3]=1.[N-:20]=[N+:21]=[N-:22].[Na+]>CS(C)=O>[Cl:19][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]1[N:20]=[N:21][N:22]=[C:2]1[N:11]([CH3:12])[CH:10]2[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 33557Sodium AzideHCID 20377605HCID 20377605, compound

Product 1

HCID 20377607HCID 20377607, compoundYield 96.5%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 2.33 g of 2,6-dichloro-3,4-dihydro-3-methyl-4-phenylquinazoline in 30 ml of dimethylsulfoxide was added 1.0 g of sodium azide. The mixture was heated at 100° C. for 3 hours and then poured into ice-water. The precipitate formed was collected by filtration, washed with water and dried to give 2.3 g of 7-chloro-4,5-dihydro-4-methyl-5-phenyltetrazolo[1,5-a]quinazoline, m.p. 280° C.

Workup

  1. customThe precipitate formed
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-d5494668cbe14dd698d2de22d6c62ab3
Source dataset
uspto-grants-1980_01
Patent number
US04183932

Reaction notes

Loading…