Imidazole → HCID 20377655, compound

Participants

Reaction Steps

36.2 g (0.113 mol) of 9-chloro-9,10-dihydro-9-(4-methylphenyl)-10-oxo-anthracene and 20.4 g (0.3 mol) of imidazole in 400 ml of absolute acetonitrile are heated under reflux for 5 hours. Thereafter, the solvent is distilled off in vacuo and the residue is taken up in 500 ml of methylene chloride. The methylene chloride solution is washed twice with 1,000 ml of water each time and the organic phase is separated off, dried over sodium sulphate and concentrated by distilling off the solvent in vacuo. The yellow, oily residue is recrystallised from 300 ml of acetonitrile. 16.5 g (40.6% of theory) of 9,10-dihydro-9-imidazol-1-yl-9-(4-methylphenyl)-10-oxo-anthracene of melting point 200°-204° C. are obtained.

Provenance & Evidence