Phosphoric Acid → HCID 86736781, compound

HRID 2052311Notes

Reaction equation

HRID 2052311 reaction equation
[P:1](=[O:5])([OH:4])([OH:3])[OH:2].[N:6]1([C:11]2([C:26]3[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=3)[C:24]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:18](=[O:25])[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:10]=[CH:9][N:8]=[CH:7]1>C(Cl)Cl>[OH:5][P:1]([O:4][P:1]([OH:4])([OH:3])=[O:2])(=[O:3])[OH:2].[N:6]1([C:11]2([C:26]3[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=3)[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:17]=3[C:18](=[O:25])[C:19]3[C:24]2=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:10]=[CH:9][N:8]=[CH:7]1

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 20377655HCID 20377655, compound

Product 1

HCID 86736781HCID 86736781, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.54 g of 85% strength phosphoric acid are added dropwise to 6 g (0.0172 mol) of 9,10-dihydro-9-imidazol-1-yl-9-(4-methylphenyl)-10-oxo-anthracene (compare Example 1) in 200 ml of methylene chloride and the mixture is subsequently stirred for 2 hours at room temperature. The solid which separates out is filtered off, washed with 150 ml of ether and 150 ml of acetone and dried over phosphorus pentoxide at 70° C. 7.8 g (83% of theory) of 9,10-dihydro-9-imidazol-1-yl-9-(4-methylphenyl)-10-oxo-anthracene diphosphate of melting point 171°-173° C. are obtained.

Workup

  1. filtrationThe solid which separates out is filtered off
  2. washwashed with 150 ml of ether and 150 ml of acetone
  3. dry with materialdried over phosphorus pentoxide at 70° C

Sources & evidence

ORD record
ord-45f98a35013749ccaaf55bf22a88574e
Source dataset
uspto-grants-1980_01
Patent number
US04183940

Reaction notes

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