Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 86736791 | HCID 86736791 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 131711707 | HCID 131711707 | — |
Reaction Steps
Add 1.0 mole of 1-isopropyl-3-methanesulfonyloxyazetidine methanesulfonate and chloroform to aqueous 1.1 M sodium bicarbonate with agitation. Saturate the aqueous phase with sodium chloride, filter and wash the solid with chloroform. Separate the phases of the combined filtrate and washes and extract the aqueous layer several times with chloroform. Dry the combined extract over sodium sulfate and filter. Add the filtrate to a solution of 1.0 mole of maleic acid in diethyl ether and warm the mixture to about 30° C. Isolate the product, 1-isopropyl-3-methanesulfonyloxyazetidine hemimaleate, by filtration and air-dry. This salt has the ratio of 1 mole 1-isopropyl-3-methanesulfonyloxyazetidine to 1 mole of maleic acid and melts within the range 115°-121° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04183923 |
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| Source dataset | uspto-grants-1980_01 |
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| ORD ID | ord-ab2a831006df4850b2e81ba128588b3b |
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| Source note | uspto-grants-1980_01 |
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