1,2-Dimethoxyethane → Ethyl Acetoacetate

Participants

Reaction Steps

To a refluxing slurry of 2.5 g (52 mmol) of 50% sodium hydride in 150 ml of DME was added 1.14 g (13 mmol) of ethyl acetate in 20 ml of DME. After a reaction period of 1.5 hours, hydrogen evolution ceased (285 ml at STP, 12.7 mmol) and the reaction mixture was worked up as described above to give a 0.47 g (62%) of crude ethyl acetoacetate, which was identified by VPC.

Provenance & Evidence