Ammonia → HCID 12557669, compound

HRID 2052382Notes

Reaction equation

HRID 2052382 reaction equation
CO[C:3]1[C:4](=[O:12])[CH:5]=[CH:6][CH:7]=[C:8]([O:10][CH3:11])[CH:9]=1.[NH3:13]>CO>[NH2:13][C:3]1[C:4](=[O:12])[CH:5]=[CH:6][CH:7]=[C:8]([O:10][CH3:11])[CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12557667HCID 12557667, compound

Product 1

HCID 12557669HCID 12557669, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

A solution of 2,4-dimethoxy-2,4,6-cycloheptatrien-1-one [described above in(b),2.4 g] in methanol (70 ml) is cooled to -25° C. and saturated with ammonia gas. The solution is heated in a pressure bottle at 80° C. for 4 hours and cooled to -70° C. The pressure bottle is opened and the solvent is evaporated to give 2-amino-4-methoxy-2,4,6-cycloheptatrien-1-one.

Workup

  1. temperaturecooled to -70° C
  2. customthe solvent is evaporated

Sources & evidence

ORD record
ord-d9c26b6ce01546c3a3263f0fea199e1c
Source dataset
uspto-grants-1980_01
Patent number
US04183955

Reaction notes

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