Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 20377833 | HCID 20377833 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 20377823 | HCID 20377823 | — |
Reaction Steps
A solution of 5-[(2-carboxyphenyl)thio]-2-methoxy-2,4,6-cycloheptatrien-1-one (1.0 g, prepared from 5-chloro-2-methoxy-2,4,6-cycloheptatrien-1-one and 2-mercaptobenzoic acid) in methanol (30 ml) at -25° C. is saturated with ammonia gas. The solution is heated in a pressure bottle at 80° C. for 8 hours and cooled to -70° C. The bottle is opened and the solvent is evaporated to give 2-amino-5-[(2-carboxyphenyl)thio]-2,4,6-cycloheptatrien-1-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04183955 |
|---|
| Source dataset | uspto-grants-1980_01 |
|---|
| ORD ID | ord-ce4e4b0832734836a78d5b6845a42f7a |
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| Source note | uspto-grants-1980_01 |
|---|
