Water → 2-Chloro-5-(trifluoromethyl)pyridine

In an autoclave were placed 2.9 g of 2-chloro-5-iodopyridine, 2.5 g of trifluoromethyl bromide dissolved in 100 ml of pyridine and 1.6 g of copper dust, and the mixture was reacted at 170° C. for 18 hours. After cooling the system, the reaction mixture was added to a suitable amount of water and extracted with methylene chloride. The extract was washed successively with water, 10% dilute hydrochloric acid, and water. After drying over anhydrous sodium sulfate, the extract was distilled to remove the methylene chloride and obtain 300 mg of 2-chloro-5-trifluoromethylpyridine.

1. temperatureAfter cooling the system
2. extractionextracted with methylene chloride
3. washThe extract was washed successively with water, 10% dilute hydrochloric acid, and water
4. dry with materialAfter drying over anhydrous sodium sulfate
5. distillationthe extract was distilled
6. customto remove the methylene chloride

ORD record

ord-161e7cb7d60745e48553d449e3013aa8

Source dataset

uspto-grants-1980_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04184041