Methyl iodide → HCID 20377886, compound

Participants

Reaction Conditions

Reaction Steps

4.4 g. of 3-[(4-fluorobenzoyl)-oxymethyl]-pyridine hydrochloride prepared according to Example 1 (a) are dissolved in 40 ml. of acetone and 3 g. of methyl iodide are added thereto. The reaction mixture is refluxed for 30 minutes and then cooled to 0° C. The precipitated quaternary salt is separated by filtration and recrystallized from 100 ml. of anhydrous ethanol. 4.2 g. of 3-[(4-fluorobenzoyl)-oxymethyl]-pyridine methyliodide (60% of theoretical yield) are obtained; m.p.: 132°-133° C.

Provenance & Evidence